Who Can Participate?
Adults aged 18 years or above
Inclusion Criteria
• Have a diagnosis of AD that has been present for ≥ 1 year
• Have a diagnosis of AD affecting ≥ 10% of body surface area (BSA)
• Have a history of inadequate response to treatment with topical medications, or medical determination that topical therapies are
inadvisable
• Have applied a stable dose of non-medicated over-the-counter emollient/moisturizer of one’s choice on their skin (except those
containing urea, camphor, or menthol) for ≥ 14 days and agrees to continue using the same moisturizer at the same frequency (ideally
once or twice daily) throughout the study
Participant Information
• Participate and receive study treatment at no cost
• Regular visits with study doctors who specialise in treating atopic dermatitis (24 visits)
• Will receive an investigative subcutaneous treatment (study drug)
• Reimbursement for study-related expenses may be provided
How Long Will The Study Last?
• 82 weeks
Carlton - Skin Health Institute
Fremantle - Fremantle Dermatology
No Doctors Found
Similar Trials
No Similar Trials FoundThe following information is from ClinicalTrials.gov
Last Update Posted: June 23, 2025
NCT07027527
Apogee Therapeutics, Inc.
Brief Summary:
The primary purpose of this study is to evaluate the safety, tolerability, and pharmacokinetic (PK) parameters of the combination of APG777 + APG990 in adults with moderate-to-severe atopic dermatitis (AD), in comparison to dupilumab. The duration of the study will be approximately 82 weeks for each participant and will consist of a Screening Period (up to 6 weeks), Treatment Period (Baseline-Week 24), and Follow-up Period (Week 28-Week 76).
Condition or Disease:
Atopic Dermatitis
Intervention/Treatment:
Drug: APG777,Drug: APG990 Drug: DupilumabPhase:
PHASE1
Ages Eligible for Study:
18 Years and older (ADULT,OLDER_ADULT)
Sexes Eligible for Study:
ALL
Inclusion Criteria
• Have a diagnosis of AD that has been present for ≥ 1 year
• Have a diagnosis of AD affecting ≥ 10% of body surface area (BSA)
• Have a history of inadequate response to treatment with topical medications, or medical determination that topical therapies are
inadvisable
• Have applied a stable dose of non-medicated over-the-counter emollient/moisturizer of one’s choice on their skin (except those
containing urea, camphor, or menthol) for ≥ 14 days and agrees to continue using the same moisturizer at the same frequency (ideally
once or twice daily) throughout the study
Terms and Conditions – ClinicalTrials.gov
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