ADX-914-203

Severe Alopecia Areata Research Trial (56 Weeks)


Treatment: Injection Age: 18 Years to 75 Years


Who Can Participate?

Adults 18-75 years with a diagnosis of severe or very severe alopecia areata (AA) may participate.

Eligibility Criteria

  • Clinical diagnosis of severe or very severe AA (50% or more total scalp hair loss)
  • Current episode of hair loss has been for more than 6 months (but less than 4 years)
  • No history or presence of hair transplants
  • Willingness to keep the same hair style and color (eg. Hair products, process, and timing of hair appointments) for the study’s duration

 What is Included?

  • No cost to participate or receive study treatment
  • Regular visits with study doctors who specialize in treating AA (26 visits)
  • May receive an investigative injection treatment (study drug)
  • Reimbursement for study-related expenses may be provided

How Long Will The Study Last?

  • 56 weeks

Note: Participants may not be engaged in any other kind of systemic, topical, or device-based therapy for AA.


Participating Locations

COUNTRY
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United States

Participating Experts

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The following information is from ClinicalTrials.gov

Last Update Posted: April 16, 2025

Official Title

A Phase 2a, Randomized, Double-blind, Placebo-Controlled, Proof-of-Concept Trial of ADX-914 for the Treatment of Severe Alopecia Areata

ClinicalTrials.gov ID

NCT06018428

Sponsor

Q32 Bio Inc.

Study Description

  • Brief Summary:

    This is a Phase IIa, Randomized, Double-blind, Placebo-controlled, multi-center Proof-of-Concept (POC) Trial in subjects with severe Alopecia Areata.

  • Condition or Disease:

    Alopecia Areata

  • Intervention/Treatment:

    Drug: ADX-914 Drug: Placebo
  • Phase:

    PHASE 2

  • Ages Eligible for Study:

    18 Years to 75 Years (ADULT,OLDER_ADULT)

  • Sexes Eligible for Study:

    ALL


Terms and Conditions – ClinicalTrials.gov
Purpose of ClinicalTrials.gov Database. The U.S. National Institutes of Health, Department of Health and Human Services, through its National Library of Medicine, has developed ClinicalTrials.gov to provide patients, family members, and members of the public current information about clinical research studies.



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